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About · Publications & Patents

Publications, inventions & copyrights.

Peer-reviewed science and issued intellectual property spanning therapeutic methods, biomarker-driven patient stratification, genome-wide target interrogation, RNA biology, and chromatin-based discovery.

Patents, Inventions & Copyrights

Issued & international intellectual property.

Co-inventor of issued and international patents spanning therapeutic methods, biomarker-driven patient stratification, genome-wide target interrogation, and chromatin-based discovery platforms.

Selected Publications · Representative 12 of 33

Peer-reviewed science.

  1. Chakraborty A, Grubb T, et al., Signoretti S, Kaelin WG. 2025. Dicarboxylic amino acid transporter is an epigenetically dysregulated nutrient carrier that sustains oncogenic metabolic programs. Nature Communications.
  2. Lambert AW, Fiore C, et al., Guenther MG#, Weinberg RA#. 2022. p63/p73 drive metastatic colonization by controlling a regenerative epithelial stem cell program in quasi-mesenchymal cancer stem cells. Developmental Cell.
  3. Beaulieu ME, Jauset T, et al., Lavigne P, Soucek L. 2019. Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-Myc therapy. Science Translational Medicine.
  4. McKeown MR, Corces MR, et al., Fritz CC, Majeti R. 2017. Super-enhancer analysis defines novel epigenomic subtypes of non-APL AML, including an RARα dependency targetable by SY-1425, a potent and selective RARα agonist. Cancer Discovery.
  5. Orlando DA, Chen MW, et al., Bradner JE, Guenther MG^. 2014. Quantitative ChIP-seq normalization reveals global modulation of the epigenome. Cell Reports.
  6. Anders LA*, Guenther MG*, et al., Jaenisch R, Young RA. 2014. Genome-wide localization of small molecules. Nature Biotechnology.
  7. Sigova AA*, Guenther MG*, et al., Sharp PA, Young RA. 2013. Divergent transcription produces most long non-coding RNAs in embryonic stem cells. Proceedings of the National Academy of Sciences.
  8. Guenther MG, Frampton GM, et al., Jaenisch R, Young RA. 2010. Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells. Cell Stem Cell.
  9. Lee TI^, Guenther MG^, et al., Jaenisch R, Young RA. 2006. Control of developmental regulators by polycomb in human embryonic stem cells. Cell.
  10. Guenther MG, Lawton L, et al., Canaani E, Young RA. 2008. Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia. Genes & Development.
  11. Guenther MG*, Levine SS*, Boyer LA, Jaenisch R, Young RA. 2007. A chromatin landmark and transcription initiation at most promoters in human cells. Cell.
  12. Boyer LA*, Lee TI*, et al., Jaenisch R, Young RA. 2005. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell.

*These authors contributed equally. ^Corresponding author. #Senior Author

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